582 The Patent Landscape Analysis of Skin Bioinks for 3D Bioprinting

Three-dimensional (3D) skin bioprinting is an emerging technology that can deposit customised biomaterials with or without desired cell types (i.e. bioinks) in 3D constructs, mimicking the skin. This study aimed to analyse granted patents for bioinks intended from 2017 2022. The were searched international patent databases [WIPO, Google Patent, European Patent Office] using keywords [‘Skin Bioink’, ‘Artificial Skin’, ‘3D Printing’, Skin Bioprinting’, ‘Biological Ink’] and then filtered by application date between exclusion criteria included used prepare artificial non-medicinal uses [engineering robotics], construction of tissues other than unspecified tissues, pending patents, manufacturing methods. selected reviewed all co-authors analysed based on their jurisdiction, publication application, assignees, bioink compositions, additional features, potential applications. In total, our search yielded 550 patents. Of these, 45 analysis. applications filed nine countries, mostly South Korea [n=20] China [n=15]. most common materials a hydrogel composition collagen [n=13] gelatin [n=8]. use vivo [n=24], vitro [n=12], both [n=5]. Given landscape particularly pre-pandemic years, expected rapidly expand near future. Within its limitations, promising innovative approach could be potentially beneficial broad range conditions, including chronic wounds, burns, cancers. prospect, also cosmetics, drug toxicity testing.